About triamcinolone acetonidea synthetic glucocorticoid, topical anti-inflammatory(steroidal). This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. it exerts more selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response. The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase a2 and thus decreases the production of prostaglandins, leukotrienes (lt), and platelet activating factor,