The antibiotic ceftriaxone is used to treat several inflammatory conditions, such as: Abdominal infections. Acute otitis media. Pelvic inflammation. prosthetic arthritis; Meningitis. Acute pyelonephritis. Prevention in surgeries. Treatment of uncomplicated gonococcal infections. neonatal conjunctivitis. Gonococcal vulvovaginitis, cervicitis, urethritis, pharyngitis, or proctitis. Urinary tract infection.