Penicillin G is used in the treatment of abscesses, actinomycosis, anthrax, bites and stings, diphtheria, endocarditis, gangrene (dead), leptospirosis, Lyme disease, meningitis, necrotizing enterocolitis, necrotizing fasciitis, neonatal conjunctivitis (if cocci) structure was sensitive), and prophylaxis in the perinatal period of Streptococcus type B, pharyngitis (or tonsillitis), pneumonia, skin infections, syphilis (neurosyphilis and congenital syphilis), tetanus, toxic shock syndrome, and Whipple's disease.